Robust regression of enzyme kinetic data
نویسندگان
چکیده
منابع مشابه
Treatment of Enzyme Kinetic Data
The concerted two-state allosteric model proposed by Monod et al. (Monod, J., Wyman, J., and Changeux, J.-P. (1965) J. Mol. Biol. 12, 88-118) is extended to expressions representing the initial velocity as a function of substrate concentration for two-substrate enzymes for which random substrate binding and rapid equilibration of all binding steps prior to a rate-determining conversion in the t...
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[email protected] Abstract Analysis of enzyme kinetic data to obtain valid information requires attention to two details that are often given less attention than they need. The first is an experimental design that ensures that the variables treated as independent are truly independent, that different interpretations can be distinguished, and that parameter values can be estimated. The second is ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1986
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2340021